13 October 2025

Aptamer Group plc

("Aptamer", the "Company" or the "Group")

New contract with top 10 pharma

£112,000 contract builds revenue visibility and reinforces Optimer® momentum

Aptamer Group plc (AIM: APTA), the developer of next-generation synthetic binders for the life sciences industry, today announces a new fee-for-service development contract valued at £112,000 with a top 10 global pharmaceutical company.

This agreement represents success-based repeat business with an existing partner, focusing on the development of Optimer® binders against two protein targets to support the partner's internal biomarker research. These binders are required to function in "real-life" biological matrices, such as muscle lysates and plasma, which are much more challenging than purified buffers used in standard laboratory tests. Success here will be a further differentiation of Optimer® from traditional antibodies.

The project follows a staged process, with potential for additional fee-for-service work for subsequent ELISA development. This builds on the Group's recent success in delivering validated Optimer® binder pairs for a top 5 pharma partner. Aptamer retains ownership supporting future licensing and royalty opportunities.

This contract builds on the strong commercial progress outlined in recent updates, including the £360,000 radiopharmaceutical contract announced on 8 October 2025 and the £315,000 in smaller contract wins in Q1. This latest agreement marks the fifth significant contract in FY26 and further diversifies the Group's revenue streams, while underscoring the growing adoption of the Optimer® platform.

The new contract adds to the existing visibility of £1.03 million in contract value for FY26, bringing the total to approximately £1.14 million, with more than two-thirds of the year remaining. The Group has a robust fee-for-service pipeline of £3.3 million, after adjusting for the closure of this deal, which includes approximately £1.0 million in late-stage discussion. These developments position the Group for continued commercial advancement, subject to project timings and conversions.

This measure of commercial performance is not indicative of full-year results, and the Group is not providing formal guidance for FY26, as contract timings, project completions and revenue recognition can vary significantly across quarters due to the nature of the business.

Dr Arron Tolley, Chief Executive Officer of Aptamer Group, commented: "This £112,000 contract with a top 10 global pharma for Optimer® binder pair development against two protein targets is aimed at biomarker research with functionality in complex matrices. This work paves the way for additional revenue for ELISA assay development and builds on our proven success with a top 5 pharma partner in this space.

The contract adds to our visibility, and our £3.3 million pipeline continues to convert, demonstrating the versatility and value of our Optimer® platform. Our emphasis is on converting the pipeline of opportunities into sustainable growth with the best potential downstream terms for the Group."

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About Aptamer Group plc

Aptamer Group is a leading developer of next-generation synthetic binders delivering innovation to the life sciences industry. The Group develops Optimer® binders, advanced molecules that work like antibodies by attaching to specific targets in the body. These binders are used in medicine, diagnostic tests, and research tools, offering benefits like high stability, reliable performance, and lower costs compared to traditional antibodies.

Aptamer operates a fee-for-service business in the US$210 billion market for antibody alternatives, working with all top 10 global pharmaceutical companies. It is also building valuable Optimer® assets with partners, aiming for future licensing revenue.

Founded in 2008, the Group listed on the London Stock Exchange AIM market in December 2021 and is headquartered in York, UK.

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