11 June 2024

Avacta Group plc

("Avacta" or the "Group" or the "Company")

Appointment of Nominated Adviser and Sole Broker

Avacta Group plc (AIM: AVCT), a life sciences company developing innovative, targeted oncology drugs and powerful diagnostics, today announces the appointment of Peel Hunt LLP as its Nominated Adviser and sole broker with immediate effect.

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About Avacta Group plc - https://www.avacta.com

Avacta Group is a UK-based life sciences company focused on improving healthcare outcomes through targeted cancer treatments and diagnostics.

Avacta has two divisions: A clinical stage oncology biotech division harnessing proprietary therapeutic platforms to develop novel, highly targeted cancer drugs, and a diagnostics division focused on supporting healthcare professionals.

Avacta has two proprietary platforms, pre|CISION™ and Affimer^®.

The pre|CISION™ platform is a highly specific substrate for fibroblast activation protein (FAP) which is highly upregulated in most solid tumours compared with healthy tissues. The pre|CISION^TM platform harnesses this tumour specific protease to activate pre|CISION^TM peptide drug conjugates and pre|CISION^TM antibody drug conjugates in the tumour microenvironment, reducing systemic exposure and toxicity, allowing dosing to be optimised to deliver the best outcomes for patients.

The lead pre|CISION™ programme AVA6000, a peptide drug conjugate form of doxorubicin, is in Phase 1 studies. It has shown a dramatic improvement in safety and tolerability compared with standard doxorubicin and preliminary signs of clinical activity.

Affimer^® is a novel biologic platform which has significant technical and commercial advantages compared with antibodies and can be used both to develop advanced immunotherapies and to improve the performance of immunodiagnostics.

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