6^th March 2025

Cambridge Cognition Holdings plc

("Cambridge Cognition", the "Company" or the "Group")

CANTAB® demonstrates substantial value in one of the largest brain health studies ever conducted

Cambridge Cognition (AIM: COG), the brain health software group specialising in digital products to advance clinical research and patient treatment, announces its involvement in one of the world's largest brain health studies, the Intuition Brain Health study¹, demonstrating the significant value of its proprietary digital cognitive assessments.

On 4^th March 2025, leading scientific journal Nature Medicine² published results from the Intuition Brain Health study, sponsored by Biogen, Inc., in collaboration with Apple, Inc. The study enrolled a representative sample of 23,004 participants across the United States and relied on Cambridge Cognition's CANTAB platform for the core cognitive assessment.

Cambridge Cognition was selected as a partner for the study for its proven ability to deliver reliable digital cognitive measurements in remote settings, highlighting the platform's unique capabilities for large-scale, unsupervised cognitive evaluation. The study demonstrates the feasibility of large-scale, cognitive assessments using smartphones alongside smartwatch technology and the significant potential to make brain health monitoring widely accessible for the general population. This validates the sensitivity of Cambridge Cognition's technology for the measurement of brain health across the lifespan.

Rob Baker, Joint Managing Director and Chief Operating Officer, commented:

"The Intuition study powerfully validates CANTAB's accuracy at scale and reinforces our leadership in digital brain health. As healthcare systems increasingly turn to digital solutions to address urgent challenges, this represents a significant opportunity which we are well positioned to meet."

This study highlights a strategically significant market opportunity for Cambridge Cognition's cognitive assessment platform, and we will be continuing to thoroughly evaluate the commercial potential for real-world brain health monitoring applications using our industry-leading software solutions in the coming months.

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About Cambridge Cognition

Cambridge Cognition is a brain health software group specializing in digital health products that advance brain health research and treatment.

The company offers four core products: CANTAB¨ assessments-providing scientifically validated, highly sensitive, precise, and objective measures of cognitive function correlated to neural networks; a flexible and proven eCOA platform with an extensive library of instruments, enabling efficient study setup and scalable data capture; rater training services that standardise assessment delivery and scoring across clinical trials and quality assurance tools that ensure data integrity by automatically detecting deviations in administration and scoring, saving time and money. These products collectively improve clinical trial outcomes, enable early patient identification, and enhance global efficiency in healthcare and pharmaceuticals.

For further information, visit: www.cambridgecognition.com