15, September 2025

Genflow Biosciences Plc 

Genflow Signs CDAs with Animal Health Companies to Advance Longevity Gene Therapy Platform

Genflow Biosciences Plc (LSE:GENF) (OTCQB:GENFF) ("Genflow" or "the Company"), the only publicly listed longevity company in Europe, today announces that it has signed two Confidential Disclosure Agreements (CDAs) with leading animal health companies to facilitate the exchange of data and initiate discussions on potential collaborations.

These CDAs mark an important milestone in Genflow's strategy to leverage its proprietary SIRT6-centenarian gene therapy platform for both human and animal health. Building on the Company's ongoing GF-1004 Dog Aging (beagle) study which has reported no adverse events to date. The agreements will provide a framework for evaluating partnership opportunities aimed at extending healthspan and improving quality of life in companion animals, a rapidly growing and high-value market segment.

Strategic Rationale

Genflow's first-in-class science, when combined with the resources of a large pharmaceutical partner, offers a faster path to commercialization therefore, derisking execution and maximizing shareholder value. Through such collaborations, Genflow can also unlock global scale, regulatory expertise, and commercial infrastructure more quickly accelerating both revenue generation and market penetration.

Dr. Eric Leire, CEO of Genflow, commented: "The signing of these CDAs reflects strong industry interest in our longevity platform and represents a further step toward building strategic partnerships in animal health. As we continue to advance GF-1004 in our canine trial, engaging with major animal health players will strengthen our pathway to potential licensing agreements and future commercialization."

Contacts

About Genflow Biosciences

Founded in 2020, Genflow Biosciences Plc. (LSE:GENF) (OTCQB:GENFF), a biotechnology company headquartered in the UK with R&D facilities in Belgium, is pioneering gene therapies to decelerate the aging process, with the goal of promoting longer and healthier lives while mitigating the financial, emotional, and social impacts of a fast-growing aging global population. Genflow's lead compound, GF-1002, works through the delivery of a centenarian variant of the SIRT6 gene which has yielded promising preclinical results. Genflow's 12-month proof-of-concept clinical trial evaluating their SIRT6-centenarian gene therapy in aged dogs began in March 2025. Other programs planned for 2025, include a clinical trial that will explore the potential benefits of GF-1002 in treating MASH (Metabolic Dysfunction-Associated Steatohepatitis), the most prevalent chronic liver disease for which there is no effective treatments. Please visit www.genflowbio.com  and follow the Company on LinkedIn and X.

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