This announcement contains inside information for the purposes of the UK Market Abuse Regulations ('UK MAR'). Upon publication of this announcement, this inside information (as defined in UK MAR) is now considered to be in the public domain. The person responsible for arranging the release of this announcement on behalf of the Company is tim mccarthy, Chief Executive Officer.

15 September 2026

ImmuPharma PLC

("ImmuPharma" or the "Company")

P140 International Patent Filing Update

ImmuPharma plc (LSE AIM: IMM), the specialist drug discovery and development company, is pleased to announce that it has filed an international Patent Cooperation Treaty ("PCT") application relating to its P140 precision medicine approach in autoimmune disease, including the identification and treatment of patients with the Type M immune profile..

Type M refers to a biologically defined patient population characterised by an immune profile associated with an increased likelihood or magnitude of response to P140.

The PCT application builds on the original UK priority patent application filed in August 2025 and announced by the Company in September 2025. The filing represents the next stage in ImmuPharma's strategy to seek international patent protection for the intellectual property arising from its work on P140 and Type M precision medicine approach.

During the 12-month priority period, ImmuPharma continued its experimental program and generated additional data supporting the scientific basis of the P140 and Type M approach. These new results have been incorporated into the PCT application.

The additional work has expanded the scientific package supporting the PCT application and contributed to the Company's broader research into the biological framework underlying P140 and autoimmune disease.

Next steps for the patent application

The PCT application will now progress through the international phase, including an international patent search and subsequent publication of the application.

The PCT process provides ImmuPharma with a route to pursue patent protection in selected national and regional jurisdictions. As the PCT application progresses, the Company will determine the key commercial territories in which it intends to enter the national and regional phases and pursue patent protection.

P140 partnering discussions

P140 remains a core value driver for ImmuPharma. The Company continues to advance discussions and remains focused on completing a value-enhancing commercial deal in 2026.

Dr Sébastien Goudreau, Chief Scientific Officer of ImmuPharma PLC, said: "The filing of the PCT application represents an important next step in protecting the intellectual property generated through our work on P140 and Type M. During the priority period, we continued to generate additional experimental data, which have now been incorporated into PCT application and further support the scientific rationale underlying our precision medicine approach. The PCT filing enables us to progress our international patent strategy alongside the broader development of P140."

Tim McCarthy, Chief Executive Officer of ImmuPharma PLC, added: "With the PCT filing now completed and additional supporting data incorporated into the application, P140 continues to progress as a key strategic asset for ImmuPharma. Our focus remains on advancing discussions and completing a value-enhancing commercial deal in 2026."

ImmuPharma will provide further updates on the P140 program as appropriate.

Notes to Editors

About ImmuPharma PLC

ImmuPharma PLC (LSE AIM: IMM) is a specialty biopharmaceutical company that discovers and develops peptide-based therapeutics. The Company's portfolio includes novel peptide therapeutics for autoimmune diseases and anti-infectives.

For additional information about ImmuPharma please visit www.immupharma.co.uk.

ImmuPharma's LEI (Legal Entity Identifier) code: 213800VZKGHXC7VUS895.

The Patent Cooperation Treaty ("PCT")

The PCT is an international patent filing system that allows an applicant to file a single international application while preserving the option to pursue patent protection subsequently in multiple national and regional jurisdictions.

During the international phase, the application undergoes an international patent search and is subsequently published. Decisions on the grant of patent protection are ultimately made by the relevant national and regional patent offices following entry into those phases.