18 June 2025

Incanthera plc

("Incanthera" or the "Company")

Breakthrough Findings on Protective Effects of Skin + CELL

Incanthera plc (AQSE: INC), the Company focused on innovative technologies in dermatology and oncology, announces breakthrough research demonstrating the protective effects of Skin + CELL against UV-induced damage in human skin cells.

An independent study run by Skin Life Analytics Ltd, Newcastle confirms that Skin + CELL protects the skin's energy centres, the mitochondria, which play a key role in overall skin health and appearance.

Key findings include:

·      UV Protection: Skin cells pre-treated with 1% Skin + CELL for six days showed a 6.5-fold reduction in mitochondrial DNA damage after solar UV exposure, indicating robust protection against cellular aging.

·      Enhanced Energy: Measurements of cell energy production using advanced technology (the Seahorse Bioanalyser) demonstrated that treated skin cells showed a marked increase in energy production, suggesting Skin + CELL not only protects but also boosts mitochondrial performance.

·      Proven Safety: Skin + CELL is well-tolerated by human skin fibroblasts, showing no harm to cells.

A series of laboratory experiments using human skin fibroblasts tested protection against sun damage by focusing on mitochondrial DNA (mtDNA), a key marker of cellular aging and UV damage.

The results demonstrate that continued use of Skin + CELL creates a shield that helps maintain the cell's core energy source and potentially reduces premature skin aging.

The protective benefits were further bolstered by measurements of cell energy production using advanced technology (the Seahorse bioanalyser).

Skin cells treated with Skin + CELL showed an impressive boost in their maximum energy production capability. This indicates the product not only protects but may also enhance the performance of the skin cells' powerhouses, thereby contributing to healthier skin.

This research highlights Skin + CELL's potential as a powerful tool in daily skincare, offering both protection and rejuvenation.

Commenting on the independent research findings, Incanthera plc CEO, Dr. Simon Ward, said:

"This study reinforces the effectiveness of our product as a potent ally in daily skincare routines.

The results demonstrate that continued use of Skin + CELL creates a shield that helps maintain the cell's core energy source and potentially reduces premature skin aging, as well as marked reduction in DNA damage after solar UV exposure.

Incanthera remains committed to researching and developing products that support vibrant, energetic skin, where skin protection and rejuvenation are within everyone's reach."

This announcement contains inside information as stipulated under the UK version of the Market Abuse Regulation no 596/2014 which is part of English law by virtue of the European (withdrawal) Act 2018, as amended. On publication of this announcement via a regulatory information service, this information is considered to be in the public domain.

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Notes to Editors

About Incanthera plc

Incanthera is a specialist company focused on innovative technologies in dermatology and oncology. It seeks to identify and develop innovative solutions to current clinical, commercially relevant unmet needs, utilising new technology from leading specialists and academic institutions as well as its in-house development team.

The Company originated from the Institute of Cancer Therapeutics ("ICT") at the University of Bradford.  Incanthera's strategy is to develop each candidate in its portfolio from initial acquisition or discovery to securing its future through commercially valuable partnerships at the earliest opportunity in its development pathway.

For more information on the Company please visit: www.incanthera.com

@incantheraplc

About Skin Life Analytics Ltd

Skin Life Analytics, based in Newcastle, is a specialist laboratory focused on advanced skin research and testing. The company provides cutting-edge analytical services to evaluate the safety, efficacy, and performance of skincare and dermatological products. With expertise in cellular biology, molecular diagnostics, and bioenergetics, Skin Life Analytics supports brands and developers in bringing scientifically validated innovations to market.

About Skin + CELL

Skin + CELL is Incanthera's luxury skincare brand utilising our ground-breaking formulation and delivery expertise, to bring scientifically proven formulations to cosmetics. Skin + CELL's complementary range of products are based on advanced, clinically designed, formulation concentrates which combine leading edge delivery enhancement technology with selected prestige cosmetic ingredients to give an effective product which gives a silky emollience in use and leaves the skin visibly radiant, energised and protected.

Incanthera's new bioactive skincare technology has been developed by our in-house experts who have previously formulated topical products for some of the world's leading skincare and pharmaceutical companies. The formulations fortify otherwise depleted physiological pathways to improve the skin's performance, ability to self-repair and to address previously unmet cosmetic conditions in skin health.

Skin + CELL's luxury skincare current range extends across face, body, hand, face serum and eye cream, and will also include bioactive SPF concentrations and further derivatives of vitamins in the future.