21 August 2025

Kistos Holdings plc

("Kistos" or "Company")

Capital Reduction update

The board of directors of Kistos Holdings plc (AIM: KIST) is pleased to announce that the reduction of capital (the "Capital Reduction") required to effect the cancellation of the Capital Reduction Shares issued by the Company prior to the Court Hearing was approved on 19 August 2025 by the High Court of Justice of England and Wales (the "Court").

The Court order confirming the Capital Reduction and a statement of capital approved by the Court in connection therewith will shortly be sent to the Registrar of Companies. The Capital Reduction will become effective upon the registration of the Court order and associated statement of capital by the Registrar of Companies. Completion of the Capital Reduction will not affect the rights attaching to the Ordinary Shares and will not result in any change to the number of Ordinary Shares in issue (or their nominal value).

Full details of the Capital Reduction are set out in the notice of annual general meeting which was sent to shareholders of the Company on 4 June 2025 (the "AGM Circular"). The AGM Circular is also available for inspection on the Kistos website, https://kistosplc.com/. Unless otherwise stated, defined terms in this announcement are the same as those set out in the AGM Circular. As set out in the AGM Circular, provisional dates were previously obtained by the Company for the required Court Hearings, which were subsequently changed at the discretion of the Company.

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