10 February 2026

Kistos Holdings plc

("Kistos" or "Company")

Release of Restricted Share Units, PDMR Dealing, Total Voting Rights

The board of directors of Kistos Holdings plc (AIM: KIST) provides notification of the following transactions, effected on 28 January 2026, relating to certain persons discharging managerial responsibility ("PDMRs") of the Company named below in respect of ordinary shares of £0.10 each in the capital of the Company ("Ordinary Shares").

The transactions relate to the release of restricted share units ("RSUs") over Ordinary Shares, each granted to those PDMRs on the 1 March 2025 pursuant to the Company's Equity Incentive Plan (the "Plan") and the subsequent sale of Ordinary Shares by those PDMRs to pay associated income tax and national insurance contribution liabilities.

Following the receipt of Ordinary Shares pursuant to the RSUs and subsequent sale of the Ordinary Shares, the PDMRs hold the following Ordinary shares, in aggregate:

Kistos further announces that an additional 62,199 Ordinary Shares have been issued to certain employees to satisfy the exercise of options and release of RSUs over Ordinary Shares by employees of the Company issued pursuant to the Plan. A total of 146,212 new Ordinary Shares have been issued under the Company's existing block admission (the "New Ordinary Shares"). The New Ordinary Shares will rank pari passu with the Company's existing Ordinary Shares.

Total voting rights

Following the issue of the New Ordinary Shares, the total number of Ordinary Shares in issue, for the purposes of the Financial Conduct Authority's ("FCA") Disclosure and Transparency Rules, is 68,282,646 with each Ordinary Share carrying the right to one vote.

In accordance with the FCA's Disclosure Guidance and Transparency Rule 5.6.1R, the above figure of 68,282,646 Ordinary Shares may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.

The information set out below is provided in accordance with the requirements of Article 19(3) of Regulation 2014/596/EU, which is part of the domestic law of the United Kingdom of Great Britain and Northern Ireland pursuant to the Market Abuse Amendment (EU Exit) Regulations (SI 2019/310).

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