5 January 2026

MedPal AI plc

("MedPal AI" or the "Company")

Trading Update - Pharmacy Operations

FDA Approves First Oral GLP-1 for Weight Loss

MedPal AI (AIM: MPAL), a UK-based digital health and artificial intelligence ("AI") company focused on health and wellness management, is pleased to provide a trading update on its pharmacy operations for December 2025 and that Novo Nordisk's Wegovy pill has now been approved by the FDA.

Trading Update - Pharmacy Operations

During December 2025, MedPal Limited processed 33,433 prescription orders through its automated pharmacy operations, generating turnover of approximately £325,000 at an average item value of £9.72. This represents month-on-month growth of approximately 16% compared with November 2025's 28,789 prescriptions, a particularly strong performance given the shortened trading month due to the Christmas period.

The continued scaling of prescription volumes reflects both the successful integration of the NHS Distance Selling Pharmacy ("DSP") contract and growing uptake of the Company's private weight loss service launched via MedPal.clinic.

FDA Approves First Oral GLP-1 for Weight Loss

On 22 December 2025, the US Food and Drug Administration ("FDA") approved Novo Nordisk's Wegovy pill (oral semaglutide 25mg), making it the first oral GLP-1 medication approved for weight management. This landmark approval represents a paradigm shift in obesity treatment, offering patients a once-daily pill alternative to weekly injections.

Clinical trials demonstrated that the oral formulation achieved weight loss of up to 16.6% in adherent patients over 64 weeks, a result that is comparable to the injectable form. The Directors believe this development will significantly expand the addressable market for GLP-1 therapies, as many patients who are reluctant to use injectable medications may now consider treatment. The oral format removes barriers such as needle aversion and refrigeration requirements, potentially bringing millions of new patients into the weight management market.

MedPal.clinic, powered by Google's Vertex AI platform, is well positioned to capitalise on this expanded market opportunity through its established AI-powered triage and prescription fulfilment capabilities.

Jason Drummond, CEO of MedPal AI, said:

"We are delighted with MedPal Limited's continued strong performance, achieving 16% month-on-month growth despite the Christmas period shortening our effective trading days. Processing approximately 33,000 prescriptions in December demonstrates the scalability and resilience of our automated dispensing infrastructure.

" We were also pleased to hear of the FDA's approval of the first oral GLP-1 for weight loss, which we expect to be transformative for the industry. By removing the barrier of injectable administration, we anticipate significant expansion of the patient population seeking treatment. MedPal.clinic's AI-first approach positions us to efficiently serve this growing market whilst maintaining the highest standards of clinical safety and patient care."

This announcement contains inside information for the purposes of Article 7 of EU Regulation 596/2014 (which forms part of domestic UK law pursuant to the European Union (Withdrawal) Act 2018). The Directors of the Company are responsible for the contents of this announcement.

Enquiries:

About MedPal AI

MedPal AI is a UK-based digital health company specialising in AI-driven wellness management. Its core app aggregates data from over 100 wearables and health apps (e.g. Apple Health, Fitbit, Garmin) into a unified profile, offering non-clinical, personalised lifestyle guidance through its AI wellness coach. The Company is also developing conversational AI to provide voice-based, real-time health insights, alerts, and recommendations.

Through its wholly owned subsidiary MedPal Limited, the Company operates a 24/7 AI-powered automated pharmacy distribution centre, providing nationwide NHS and private prescription services. The facility leverages advanced robotic dispensing technology integrated with AI triage to deliver rapid, cost-effective medication fulfilment with same-day and next-day delivery capabilities.

MedPal AI has a partnership agreement with Epassi UK Limited, which will, for a limited time, grant exclusive, zero-cost access to the MedPal AI app across Epassi's network of 11M+ employees at major firms like Siemens and Volvo. Beyond consumers, MedPal AI plans to expand via B2B licensing to healthcare providers, businesses, and insurers, with potential use in insurance-linked wellness programs to reduce premiums and drive new revenue through institutional partnerships. The Company also has a partnership agreement with Independent Gyms Ltd.

Forward Looking Statements

This announcement contains forward-looking statements relating to expected or anticipated future events and anticipated results that are forward-looking in nature and, as a result, are subject to certain risks and uncertainties, such as general economic, market and business conditions, competition for qualified staff, the regulatory process and actions, technical issues, new legislation, uncertainties resulting from potential delays or changes in plans, uncertainties resulting from working in a new political jurisdiction, uncertainties regarding the results of exploration, uncertainties regarding the timing and granting of prospecting rights, uncertainties regarding the timing and granting of regulatory and other third party consents and approvals, uncertainties regarding the Company's or any third party's ability to execute and implement future plans, and the occurrence of unexpected events.