Oxford BioDynamics
("OBD" or the "Company" and, together with its subsidiaries, the "Group")

Issue of shares in lieu of salary,

Director / PDMR shareholdings &

Total voting rights

Oxford, UK - 24 December 2024 - Oxford BioDynamics, Plc (AIM: OBD, the Company), a precision clinical diagnostics company bringing specific and sensitive tests to the practice of medicine based on OBD's EpiSwitch® 3D genomics platform, announces the issue of 2,742,657 ordinary shares of 1 pence each ("Ordinary Shares") at a price of 1.1 per share (the "New Ordinary Shares") to its directors, PDMRs and certain other senior staff members to satisfy part of their salaries and fees, in line with the Company's ongoing strategy to preserve its cash resources as announced on 14 October 2024. The issue price is equal to the closing market price of the Company's Ordinary Shares on 23 December 2024, being the last practicable date prior to the issue of the New Ordinary Shares.

The New Ordinary Shares being issued have been allocated to the following directors and PDMRs:

Application has been made for the New Ordinary Shares to be admitted to trading on AIM ("Admission") and it is expected that Admission will occur at 8.00 a.m. on or around 31 December 2024. The New Ordinary Shares have been issued as fully paid and rank pari passu in all respects with the existing Ordinary Shares.

Following Admission, the Company's issued share capital will consist of 319,319,226 Ordinary Shares. There are no shares held in treasury. Therefore, the Company's total number of Ordinary Shares in issue and voting rights will be 319,319,226 and this figure may be used by Shareholders from Admission as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.

Further details of the PDMR dealings are included below. This information has been provided in accordance with Article 5(1)(b) of the Market Abuse Regulation (EU) No 596/2014 which is part of UK law by virtue of the European Union (Withdrawal) Act 2018.

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For more information:

Notes for Editors

About Oxford BioDynamics Plc

Oxford BioDynamics Plc (AIM: OBD) is an international biotechnology company, advancing personalized healthcare by developing and commercializing precision clinical diagnostic tests for life-changing diseases.

Currently OBD has two commercially available products: the EpiSwitch® PSE (EpiSwitch Prostate Screening test) and EpiSwitch® CiRT (Checkpoint Inhibitor Response Test) blood tests. PSE boosts the predictive accuracy of a PSA test from 55% to 94% when testing the presence or absence of prostate cancer. CiRT is a highly accurate (85%) predictive response test to immuno-oncology checkpoint inhibitor treatments.

The tests are based on OBD's proprietary 3D genomic biomarker platform, EpiSwitch® which enables screening, evaluation, validation and monitoring of biomarkers to diagnose patients or determine how individuals might respond to a disease or treatment.

OBD's clinical smart tests have the potential to be used across a broader range of indications, and new tests are being developed in the areas of oncology, neurology, inflammation, hepatology and animal health.

The Group's headquarters and UK laboratories are in Oxford, UK. Its US operations and clinical laboratory are in Maryland, USA, along with a reference laboratory in Penang, Malaysia.

OBD is listed on the London Stock Exchange's AIM (LSE: OBD). For more information, please visit the Company's website, www.oxfordbiodynamics.com,  X (@OxBioDynamics) or LinkedIn.

The notifications below, made in accordance with the requirements of the UK Market Abuse Regulation, provides further detail.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them.