1 June 2026

ProBiotix Health plc

("ProBiotix" or the "Company")

New Partnership Agreement in Slovakia

ProBiotix Health plc (AQSE: PBX), the life sciences business developing probiotics to support cardiometabolic health, is pleased to announce a new partnership agreement with Slovakia based iProbio.

ProBiotix has secured a commercial cooperation with iProbio to supply its patented probiotic strain LP_LDL® for a new cardiometabolic health food supplement branded as CARDIObiom+®, a product developed by the iProbio consumer brand of PerBiotiX s.r.o., a leading Slovak based probiotics company.

Cardiovascular disease mortality in Slovakia is estimated to be around 50% higher than the EU average, while hypercholesterolaemia is estimated to affect approximately 49% of adults in the country1, reinforcing the importance of supporting cardiovascular and metabolic health. CARDIObiom+® was officially launched in Slovakia to coincide with World Hypertension Day, and a global awareness campaign focused on cardiovascular health.

After an extensive evaluation of clinically validated ingredients in the cardiometabolic space, iProbio selected LP_LDL® for its robust clinical evidence in supporting healthy cholesterol levels. CARDIObiom+® combines LP_LDL® with a standardised polyphenol-rich extract of lemon verbena (Aloysia citrodora) and hibiscus (Hibiscus sabdariffa), together with vitamin D3 and vitamin B1, in a dual-capsule daily dose designed to support cholesterol metabolism, lipid and glucose metabolism, and overall metabolic balance.

The new product will initially be distributed in Slovakia through iProbio's direct e-commerce channel, with further distribution spanning pharmacies, health food stores, and partner retailers. ProBiotix will supply its active ingredient LP_LDL® whereupon iProbio will be responsible for manufacturing, packaging and branding of the product. Further expansion beyond Slovakia is expected in the Czech Republic and in additional Central European markets.

¹ Source: European Society of Cardiology

Steen Andersen, CEO of ProBiotix Health, commented: "Our partnership with iProbio to supply our unique LP_LDL® strain to be used in their new CARDIObiom+® product is further validation of the growing scalability of our business.

"Increasing awareness of the need to focus on cardiovascular health is critical, and with this partnership agreement we are very pleased that we can help advance further awareness and increase sales in new geographic territories."

Martin Haranta, CEO of iProbio, added: "CARDIObiom+® represents a natural next step for iProbio. After more than 40 years of microbiome research, we wanted to expand our targeted probiotic portfolio into the field of cardiometabolic health - a segment where there is strong scientific evidence as well as a clear consumer need.

"LP_LDL® is a probiotic strain with clinically validated effects supporting cholesterol metabolism, and our partnership with ProBiotix Health has provided us with confidence both in the scientific foundation and in supply reliability. The product launch on World Hypertension Day also allowed us to naturally connect with the ongoing conversation among Slovak consumers about heart health and metabolic balance. We look forward to further developing this collaboration."

This announcement contains information which, prior to its disclosure, was considered inside information for the purposes of the UK Market Abuse Regulation and the Directors of the Company are responsible for the release of this announcement.

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Notes to Editors:

ProBiotix Health is a life sciences company that develops probiotic formulations to support cardiometabolic health. Since its formation, ProBiotix has become recognised as a global leader in microbiome modulating probiotics for use in food supplements and nutraceuticals.

The Company has a unique approach; discovering ground breaking probiotics, ensuring their benefits through robust science, and bringing to market effective finished probiotic-based products for human health across the globe.

About iProbio

iProbio is the consumer brand of PerBiotiX s. r. o., a Slovak life sciences company specialising in personalised probiotics, targeted probiotics, prebiotics, flavobiotics and essential food supplements. The company is headquartered in Čadca, Slovakia (Palárikova 2657, 022 01 Čadca; IČO 53074980). Its heritage in microbiome research dates back to 1984, representing more than 40 years of continuous scientific work. PerBiotiX s.r.o. is associated with the organisation of the International Probiotic Conference (IPC), one of the world's longest-running scientific gatherings dedicated to probiotics, now in its 25th+ year.

The company was co-founded by Alojz Bomba (Scientific Director), Martin Haranta (CEO), and Norbert Bomba (CBDO), and is led by Martin Haranta as CEO. The company primarily operates in the Slovak market, with active expansion into the Czech Republic and other Central European markets.