Jonathan BuntingAward02/02/20261,003,757 shares£0.00Richard ClayAward02/02/2026575,436 shares£0.00Richard ClayAward02/02/2026653,905 shares£0.00Jonathan BuntingAward02/02/20261,003,757 shares£0.00Deborah RabeyPurchase12/12/202513,866 shares£9,912.80Jonathan BuntingSale28/11/2025165,458 shares£1,145.63Jonathan BuntingSale03/12/2025442,530 sharesManju MalhotraPurchase14/11/202530,006 shares£19,893.98DateDirector/PDMRTypeSharesPriceValue02/02/2026Jonathan BuntingAward1,003,7570.00£0.0002/02/2026Richard ClayAward575,4360.00£0.0002/02/2026Richard ClayAward653,9050.00£0.0002/02/2026Jonathan BuntingAward1,003,7570.00£0.0012/12/2025Deborah RabeyPurchase13,86671.49£9,912.8028/11/2025Jonathan BuntingSale165,4580.69£1,145.6303/12/2025Jonathan BuntingSale442,530––14/11/2025Manju MalhotraPurchase30,00666.30£19,893.98
Open positions onlyAberforth Partners LLP12/12/202442,612,667 shares17.21%FORUM Family Office Value Fund Investmentgesellschaft mit variablem Kapital (Société d'investissement à capital variable, SICAV)08/11/202422,080,493 shares8.92%M&G Plc06/11/202413,218,716 shares5.34%FIL Limited14/10/202412,312,375 shares4.97%The Wellcome Trust Limited as trustee of The Wellcome Trust15/12/20236,617,358 shares2.67%The Wellcome Trust Limited as trustee of The Wellcome Trust03/07/20239,396,858 shares3.79%DateShareholderShares HeldPercentage12/12/2024Aberforth Partners LLP42,612,66717.21%08/11/2024FORUM Family Office Value Fund Investmentgesellschaft mit variablem Kapital (Société d'investissement à capital variable, SICAV)22,080,4938.92%06/11/2024M&G Plc13,218,7165.34%14/10/2024FIL Limited12,312,3754.97%15/12/2023The Wellcome Trust Limited as trustee of The Wellcome Trust6,617,3582.67%03/07/2023The Wellcome Trust Limited as trustee of The Wellcome Trust9,396,8583.79%
Jonathan BuntingAward02/02/20261,003,757 shares£0.00Richard ClayAward02/02/2026575,436 shares£0.00Richard ClayAward02/02/2026653,905 shares£0.00Jonathan BuntingAward02/02/20261,003,757 shares£0.00Deborah RabeyPurchase12/12/202513,866 shares£9,912.80Jonathan BuntingSale28/11/2025165,458 shares£1,145.63Jonathan BuntingSale03/12/2025442,530 sharesManju MalhotraPurchase14/11/202530,006 shares£19,893.98DateDirector/PDMRTypeSharesPriceValue02/02/2026Jonathan BuntingAward1,003,7570.00£0.0002/02/2026Richard ClayAward575,4360.00£0.0002/02/2026Richard ClayAward653,9050.00£0.0002/02/2026Jonathan BuntingAward1,003,7570.00£0.0012/12/2025Deborah RabeyPurchase13,86671.49£9,912.8028/11/2025Jonathan BuntingSale165,4580.69£1,145.6303/12/2025Jonathan BuntingSale442,530––14/11/2025Manju MalhotraPurchase30,00666.30£19,893.98
Open positions onlyAberforth Partners LLP12/12/202442,612,667 shares17.21%FORUM Family Office Value Fund Investmentgesellschaft mit variablem Kapital (Société d'investissement à capital variable, SICAV)08/11/202422,080,493 shares8.92%M&G Plc06/11/202413,218,716 shares5.34%FIL Limited14/10/202412,312,375 shares4.97%The Wellcome Trust Limited as trustee of The Wellcome Trust15/12/20236,617,358 shares2.67%The Wellcome Trust Limited as trustee of The Wellcome Trust03/07/20239,396,858 shares3.79%DateShareholderShares HeldPercentage12/12/2024Aberforth Partners LLP42,612,66717.21%08/11/2024FORUM Family Office Value Fund Investmentgesellschaft mit variablem Kapital (Société d'investissement à capital variable, SICAV)22,080,4938.92%06/11/2024M&G Plc13,218,7165.34%14/10/2024FIL Limited12,312,3754.97%15/12/2023The Wellcome Trust Limited as trustee of The Wellcome Trust6,617,3582.67%03/07/2023The Wellcome Trust Limited as trustee of The Wellcome Trust9,396,8583.79%
