TheraCryf plc

("TheraCryf", the "Company" or the "Group")

Marking Addiction Awareness Week 2025

Alderley Park, 26 November 2025 - TheraCryf plc (AIM: TCF), the clinical stage drug development company focussing on brain disorders, is supporting Addiction Awareness Week.

23-30 November is the UK's national Addiction Awareness Week 2025, aiming to raise awareness of the challenges and stigma around addiction.

Addictions, particularly Substance Use Disorders, are a chronic, relapsing group of disorders with a high unmet medical need.  The number of people affected is astonishing, with up to 2.2% of the global population estimated to have a Substance Use Disorder[1]. Current treatments often see high relapse rates, and there are limited long-term pharmacological options.

Last year in the UK, addiction was the cause of more deaths than road traffic collisions, and it costs the economy more than £21bn per year. Alcohol addiction alone costs the NHS more than £3.5bn per year.

TheraCryf is honoured to be contributing to the potential treatment of addiction with its lead Ox-1 orexin -1 blocker programme, targeting binge eating disorder and other substance use disorders.

As noted earlier this month, the programme is progressing on budget and ahead of schedule, with the 0.5kg scale-up completed ahead of schedule, manufacturing of 2kg human grade material initiated and the scale-up to 10kg manufacturing proceeding to plan. This is with our aim of achieving clinic readiness by the end of 2026.

TheraCryf has also has robust patent protection for Ox-1, with the recent patent grant in Korea, complementing long lasting patent protection in all major territories including Europe and USA.

Dr Huw Jones, CEO of TheraCryf, said:

"In marking Addiction Awareness Week, we are conscious of the very real unmet medical need in addiction. Addictive disorders affecting hundreds of millions of people and their families across the world, with the global cost burden running into many tens of billions. We are focused on helping to reduce both the human and financial costs of these conditions and getting our promising Ox-1 programme into the clinic as soon as possible."

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About TheraCryf plc

TheraCryf is the clinical stage drug development company focussing on brain disorders. The Company has a broad clinical and preclinical pipeline in indications including addiction, anxiety, fatigue, narcolepsy, glioblastoma* and neurodevelopmental disorders [*orphan indication].

The Company's strategy is to generate compelling data sets to preclinical and/or clinical proof of concept and partner its clinical programmes with mid-size to large pharma for larger trials and commercialisation. It also has a number of industry partnerships with companies, including Stalicla SA, in neurodevelopmental disorders.  The Company has sourced know-how for programmes from companies such as Shire (now Takeda).

TheraCryf has worked with and has ongoing collaborations with major universities and hospitals such as the University of Manchester, La Sapienza (Università di Roma), the Erasmus Medical Centre, Rotterdam, Kings College London and the University of Michigan.

The Company has its headquarters and registered office at Alderley Park, Cheshire. It is quoted on AIM in London and trades under the ticker symbol TCF.