30 September 2026

TheraCryf plc

("TheraCryf", the "Company" or the "Group")

Posting of Annual Report and Notice of AGM

TheraCryf plc, the biotech company developing new medicines for addiction and other neuropsychiatric disorders, announces that its Annual Report and Accounts for the year ended 31 March 2026 and Notice of the Annual General Meeting have been posted to shareholders and are now available on the Company website at https://theracryf.com/investors/.

The Company's Annual General Meeting will take place at 2.00 pm on Thursday, 22 October 2026 at Smithfield Offices, 5 St John’s Lane, London, EC1M 4BH.

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About TheraCryf

TheraCryf plc is a biotechnology company developing new medicines for addiction and other neuropsychiatric disorders, areas of significant unmet medical need.

The Group’s lead programme is a novel, best-in-class orexin-1 receptor antagonist being developed as a potential treatment for addiction, including binge eating, alcohol and other substance use disorders.

The programme has already been heavily de-risked for both safety/tolerability and efficacy in previous testing and is fully funded through final pre-clinical trials to clinical readiness, with regulatory submissions for first in man studies targeted for 2026.

TheraCryf also has a dopamine transporter (DAT) modulator programme addressing fatigue of brain origin, including fatigue associated with multiple sclerosis, chemotherapy and narcolepsy. The Group also has a legacy, grant-funded, oncology programme in glioblastoma with SFX-01.

The Group operates a capital-light, virtual development model advancing programmes to early clinical or proof-of-concept stage before partnering with commercially focused pharmaceutical and biotechnology companies.

TheraCryf’s headquarters and registered office are at Alderley Park, Cheshire.

For further information, visit: https://theracryf.com