Banco Santander, S.A., in compliance with the Securities Market legislation, hereby communicates the following:

OTHER RELEVANT INFORMATION

End of the Buy-back Programme

Reference is made to our notice of inside information of 6 October, 2021 (official registry number 1086) relating to the buyback programme of own shares (the "Buy-back Programme" or the "Programme") approved by the Board of Directors of Banco Santander, S.A. (the "Company" or "Banco Santander"). Banco Santander informs that, after the last acquisitions mentioned below, the maximum investment provided for in the Buy-back Programme, i.e. 841 million euros was reached, implying the acquisition of a total of 259,930,273 own shares, representing approximately 1.499% of the Company's share capital. The acquisition of shares under the Buy-back Programme has been communicated on a regular basis, pursuant to the provisions of article 2.2 and 2.3 of the Commission Delegated Regulation (EU) No. 2016/1052. The Buy-back Programme has therefore been terminated as a consequence of the above and in accordance with the terms set out when it was announced.

As disclosed when the Buy-back Programme was launched, its purpose was to reduce the Bank's share capital by redeeming the shares acquired under the Buy-back Programme in a capital reduction expected to be submitted for approval at the 2022 Ordinary General Shareholders' Meeting.

Last transactions executed under the Programme. 

Moreover, pursuant to article 5 of Regulation (EU) no. 596/2014 on Market Abuse of 16 April 2014, and articles 2.2 and 2.3 of Commission Delegated Regulation (EU) 2016/1052, of 8 March 2016, the Company informs -on the basis of the information received from Morgan Stanley Europe SE as intermediary in charge of executing the Buy-back Programme- that the transactions executed as part of the Buy-back Programme, between 19 and 25 November 2021 (both included) were as follows:

Issuer name: Banco Santander, S.A. - LEI 5493006QMFDDMYWIAM13

Reference of the financial instrument: ordinary shares - Code ISIN ES0113900J37

Detailed information of the transactions carried out within the referred period is attached as Annex I.

Boadilla del Monte (Madrid), 26 November 2021

ANNEX I

Detailed information on each of the transactions carried out within the context of the Buy-back Programme between 19^th and 25^th November,  2021 (both included)