Banco Santander, S.A., in compliance with the Securities Market legislation, hereby communicates the following:

OTHER RELEVANT INFORMATION

Banco Santander, S.A. (the "Issuer") hereby announces that it intends to carry out on 8 July 2022 the total redemption and cancellation of the following issuances:

(i)         "Issuance of Banco Santander, S.A Territorial Covered Bonds Series 18ª - June 2020" with ISIN code ES0413900665, for a total amount of two billion euros (EUR 2,000,000,000), the Final Conditions of which were registered with the registries of the Spanish National Securities Market Commission on 2 June 2020;

(ii)        "Issuance of Banco Santander, S.A Territorial Covered Bonds Series 20ª - July 2020" with ISIN code ES0413900681, for a total amount of two billion euros (EUR 2,000,000,000), the Final Conditions of which were registered with the registries of the Spanish National Securities Market Commission on 14 July 2020;

(iii)       "Issuance of Banco Santander, S.A Territorial Covered Bonds Series 22ª - May 2021" with ISIN code ES0413900715, for a total amount of one billion euros (EUR 1,000,000,000), the Final Conditions of which were registered with the registries of the Spanish National Securities Market Commission on 18 May 2021.

The redemption and cancellation to be carried out on 8 July 2022 will be implemented through the early cancellation of each of the territorial covered bonds, which constitute the issuances described above, being all of them held by the Issuer.

This is hereby reported as other relevant information for the appropriate purposes.

Boadilla del Monte (Madrid), 29 June 2022