| Liontrust Asset Management Plc | 2,218,164 | 13.97% | |
| Gresham House Asset Management Limited | 3,884,684 | 24.47% | |
| Liontrust Asset Management Plc | 2,350,200 | 14.80% | |
| Nortrust Nominees Ltd | 1,606,852 | 10.12% | |
| Gresham House Asset Management Limited | 3,746,521 | 23.60% | |
| Liontrust Asset Management Plc | 2,496,303 | 15.72% | |
| Liontrust Investment Partners LLP | 2,502,053 | 15.76% | |
| Liontrust Asset Management Plc | 2,502,053 | 15.76% | |
| Liontrust Asset Management Plc | 2,502,053 | 15.76% | |
| Liontrust Asset Management Plc | 2,502,053 | 15.75% | |
| Gresham House Asset Management Limited | 3,544,601 | 22.23% | |
| Liontrust Asset Management Plc | 2,588,125 | 16.23% | |
| Liontrust Asset Management Plc | 2,662,641 | 16.66% | |
| Liontrust Asset Management Plc | 2,662,641 | 16.66% | |
| The Wellcome Trust Limited as trustee of The Wellcome Trust | 805,370 | 5.03% | |
| Gresham House Asset Management Limited | 3,371,037 | 21.01% | |
| Liontrust Asset Management Plc | 2,824,988 | 17.60% | |
| Gresham House Asset Management Limited | 3,285,037 | 20.46% | |
| Liontrust Asset Management Plc | 2,824,988 | 17.59% | |
| Liontrust Asset Management Plc | 2,914,864 | 18.14% | |
| The Wellcome Trust Limited as trustee of The Wellcome Trust | 668,994 | 4.16% | |
| The Wellcome Trust Limited as trustee of The Wellcome Trust | 500,190 | 3.11% | |
| Artemis Investment Management LLP | 844,214 | 5.14% | |
| Artemis Investment Management LLP | – | 4.59% | |
| Octopus Investments Limited | 328,047 | 1.99% | |
| Gresham House Asset Management Ltd | 3,278,602 | 19.92% | |
| Northern Trust | 938,000 | 5.69% | |
| Octopus Investments Limited | 2,335,294 | 14.18% | |
| Artemis Investment Management LLP | – | 3.17% | |
| Octopus Investments Limited | 2,307,806 | 13.98% | |
| Aberforth Partners LLP | 898,030 | 5.44% | |
| Discretionary Clients | 780,008 | 4.72% | |
| Gresham House Asset Management Ltd | 2,368,347 | 14.38% | |
| Octopus Investments Limited | 2,466,974 | 14.98% | |
| Gresham House Asset Management Ltd | 2,149,890 | 13.05% | |
| Gresham House Asset Management Ltd | 2,092,226 | 12.72% | |
| Gresham House Asset Management Ltd | 1,856,292 | 11.28% | |
| Octopus Investments Limited | 2,623,629 | 15.99% | |
| Liontrust Asset Management Plc | 3,101,939 | 18.91% | |
| Gresham House Asset Management Ltd | 907,138 | 5.58% | |
| FIL Limited | 786,452 | 4.83% | |