hVIVO plc

(“hVIVO”, the “Company" or the “Group”)

Board Changes

London, UK – 22 September 2026, hVIVO plc (AIM: HVO), a purpose-built, full-service international clinical development partner and the world leader in human challenge trials, today announces the following changes to the Board as part of the ongoing evolution of its composition.

-          Appointment of Caroline Shaw, CBE as Independent Non-Executive Director, effective from 1 October 2026. Caroline will also serve as Chair of the Remuneration Committee and as a member of the Audit Committee

-          Elaine Sullivan to step down as Independent Non-Executive Director, effective from 1 October 2026

Appointment of Caroline Shaw, CBE: Caroline brings more than 30 years’ senior healthcare leadership experience across the NHS, independent healthcare, digital health and life sciences. She has held Chief Executive and board-level roles in both the public and private sectors, with expertise spanning strategy, clinical governance, operational transformation and commercial growth.

Her prior roles include Chief Executive Officer of Evergreen Life where she led a successful turnaround to profitability; Chief Executive Officer of Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust; Chief Operating Officer / Deputy Chief Executive Officer of Nottingham University Hospitals NHS Trust; and Chief Executive Officer of The Christie NHS Foundation Trust.

Resignation of Elaine Sullivan: Concurrently, Elaine Sullivan will step down as an independent Non-Executive Director. Elaine joined the Board of hVIVO (then part of Open Orphan) in November 2020 and has previously served as Senior Independent Director and Chair of the Remuneration Committee.

Shaun Chilton, Non-Executive Chair of hVIVO plc, said: “On behalf of the Board, I would like to thank Elaine for her contribution to hVIVO over the past six years during a period of strategic transformation. We wish her every success for the future.

"We are delighted to welcome Caroline Shaw to the Board.  Her extensive clinical, operational and commercial leadership experience will be valuable as we continue to develop hVIVO’s broader, integrated clinical development platform and realise the significant opportunities it has to offer.”

Additional Information on the Board Appointment

The following additional information is provided with regards to the appointment of Caroline Sarah Shaw, aged 59, in accordance with Rule 17 and Schedule 2(g) of the AIM Rules for Companies:

Caroline Shaw does not hold any shares or options in the Company. There are no further disclosures required under Rule 17 and Schedule 2(g) of the AIM Rules for Companies.

For further information please contact:

Notes to Editors

About hVIVO

hVIVO plc (AIM: HVO) is a purpose-built, full-service international clinical development partner and the global leader in human challenge trials, serving seven of the world's ten largest biopharma companies.

The Company has an end-to-end platform designed to bring important medicines to patients faster: spanning preclinical strategy, first‑in‑human studies, Phase II patient trials and specialist laboratory services, delivered through a large participant database, wholly owned sites and laboratories across the UK and Germany.

With a combined Group heritage of more than 100 years, hVIVO delivers an accelerated pathway to clinical proof-of-concept through four integrated service lines: Consulting, Clinical Trials, Human Challenge Trials, and Laboratories.

• Consulting provides expert-led preclinical and clinical strategy, encompassing non-clinical, clinical, CMC, pharmacokinetics, data management, biostatistics, and regulatory support to guide trial design, execution, and interpretation.
• Clinical Trials offers Phase I/II CRO services, Phase II/III site services across the UK and Germany, and specialist recruitment through FluCamp, Europe's largest recruitment database.
• Human Challenge Trials leverages hVIVO’s state-of-the-art quarantine facility in London – the largest of its kind worldwide – to deliver fast, controlled, high-quality efficacy data through guaranteed viral exposure.
• Laboratories provides cutting-edge virology and immunology laboratory services, including biobanking and sample storage, supporting both challenge trials and standalone client studies.