5 October 2021

Oxford Nanopore Technologies plc (the "Company")

Block Listing Application

Directorate Change

Application has been made to the Financial Conduct Authority (FCA) and to the London Stock Exchange for up to 40,000,000 ordinary shares of £0.0001 each in the capital of the Company (the "Block Listing Shares") to be admitted to the standard listing segment of the Official List of the FCA and to trading on the London Stock Exchange's main market for listed securities using a block listing (the "Block Listing Admission").

The Block Listing shares will, upon issue, rank equally with all other ordinary shares of £0.0001 each in the capital of the Company that are then in issue.

The Block Listing shares will be issued by the Company from time to time under the terms of:

-     the Oxford Nanopore Technologies Limited Share Option Scheme;

-     the Oxford Nanopore Technologies Limited Share Option Plan 2018;

-     the Metrichor Limited Share Option Scheme;

-     the Oxford Nanopore Technologies plc Long-Term Incentive Plan 2021;

-     the Oxford Nanopore Technologies plc Deferred Bonus Plan 2021;

-     the Oxford Nanopore Technologies plc Share Incentive Plan 2021; and

-     the Oxford Nanopore Technologies plc Employee Stock Purchase Plan 2021.

The Block Listing Admission is expected to become effective on 6 October 2021.

The Company also hereby confirms that, as previously disclosed by the Company, Alan Aubrey has retired from the Board as Non-Executive Director with effect from 5 October 2021.

For further information please contact:

Oxford Nanopore Technologies plc

[email protected]