29 February 2024

Oxford Nanopore Technologies plc

("Oxford Nanopore" or the "Company")

Directorate Change

Oxford Nanopore Technologies plc (LSE: ONT), the company delivering a new generation of nanopore-based molecular sensing technology, today announces the retirement of three Directors from the Board: Dr James ("Spike") Willcocks, Clive Brown, and Tim Cowper. Clive will step off the Board with immediate effect while Spike and Tim will not stand for re-election at the 2024 AGM and will retire from the Board at the conclusion of the AGM in June 2024. All three Directors will remain in their operational leadership roles at Oxford Nanopore: Spike as Chief Strategy Officer, Clive as Chief Technology, Innovation and Product Officer and Tim as Chief Operating Officer. Each will also continue to serve on the Company's Operating Committee.

These changes are part of normal Board evolution and in line with best practice governance.

Spike has served on the Board for 18 years and Clive and Tim have each served for five years.

Duncan Tatton-Brown, Chair of Oxford Nanopore, commented: "I would like to thank Spike, Clive and Tim for their outstanding support and contribution to the Board during their long tenure and specifically in the transition period since IPO. They have played a foundational role in building this Company, and we are grateful for their ongoing dedication and leadership."

As before and in line with the Company's delegation of authority, the Company has determined that only Directors are Persons Discharging Managerial Responsibilities (PDMRs). Following retirement from the Board, Clive, Spike and Tim will no longer be PDMRs.

Oxford Nanopore is committed to Board diversity, and this evolution will also progress towards fulfilling the Company's goal of reaching 40% female Board representation. Following the AGM, the Board will include two executive Directors and seven non-executive Directors, three of whom are women.

This announcement is made pursuant to Listing Rule 9.6.11R.

[ENDS]

For further information, please contact:

Oxford Nanopore Technologies plc

Investors:          ir@nanoporetech.com

Media:               media@nanoporetech.com

Teneo

Tom Murray, Olivia Peters

+44 (0) 20 7353 4200

OxfordNanoporeTechnologies@teneo.com