LEI: 549300Q7EXQQH6KF7Z84

10 January 2025

RTW Biotech Opportunities Ltd

New Investment in Series A of Alesta Therapeutics

RTW Biotech Opportunities Ltd (the "Company"), a London Stock Exchange-listed investment company focused on identifying transformative assets with high growth potential across the life sciences sector, is pleased to note a new portfolio company investment in Alesta Therapeutics ("Alesta"), a Netherlands-based biotechnology company committed to developing novel oral small molecule therapies for underserved rare diseases. Alesta announced the completion of its €65 million (US$67 million) Series A financing round, in which the Company participated alongside other investment vehicles managed by RTW Investments, LP (the "Investment Manager"). The funds will enable Alesta to advance its lead asset toward clinical proof of concept and accelerate the development of a second asset.

Alesta's lead asset, ALE1, is being developed for hypophosphatasia (HPP), a rare genetic disorder with significant unmet needs. It is also advancing ALE2, a promising candidate to treat Charcot-Marie-Tooth (CMT) disease.

Roderick Wong, Managing Partner and CIO at the Investment Manager said, "We are thrilled to participate in Alesta's Series A round. The innovative approach and compelling preclinical data for ALE1 demonstrate significant potential to address critical unmet needs in rare diseases. We are eager to support Alesta's journey and its efforts to bring transformative therapies to patients who need them most."

The full text of the announcement can be accessed at https://alestatherapeutics.com.

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About Biotech Opportunities Ltd:

RTW Biotech Opportunities Ltd (LSE: RTW) is an investment fund focused on identifying transformative assets with high growth potential across the biopharmaceutical and medical technology sectors. Driven by a long-term approach to support innovative businesses, RTW Biotech Opportunities Ltd invests in companies developing next-generation therapies and technologies that can significantly improve patients' lives. RTW Biotech Opportunities Ltd is managed by RTW Investments, LP, a leading healthcare-focused entrepreneurial investment firm with deep scientific expertise and a strong track record of supporting companies developing life-changing therapies.

Visit the website at www.rtwfunds.com/rtw-biotech-opportunities-ltd for more information.

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The information in this announcement may include forward-looking statements, which are based on the current expectations and projections about future events, and in certain cases can be identified by the use of terms such as "may", "will", "should", "expect", "anticipate", "project", "estimate", "intend", "continue", "target", "believe" (or the negatives thereon) or other variations thereon or comparable terminology. These forward-looking statements, as well as those included in any related materials, are subject to risks, uncertainties and assumptions about the Company and/or its underlying investments, including, among other things, the development of the applicable entity's business, trends in its operating industry, expected use of financing proceeds and future capital expenditures and acquisitions. In light of these risks, uncertainties and assumptions, the events in the forward-looking statements may not occur.

The information contained in this announcement is given at the date of its publication (unless otherwise marked). No reliance may be placed for any purpose whatsoever on the information or opinions contained in this announcement or on its completeness, accuracy or fairness.

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