LEI: 549300Q7EXQQH6KF7Z84

31 October 2025

RTW Biotech Opportunities Ltd

Royalty Funding Agreement with Savara Inc.

·      Savara announces $75m funding agreement with funds managed by RTW

·      Subject to FDA approval of MOLBREEVI, a treatment for rare lung disease

·      RTW Bio will participate through its investment in 4010 Royalty Fund

RTW Biotech Opportunities Ltd (the "Company"), the London Stock Exchange-listed investment company focused on identifying transformative assets with high growth potential across the life sciences sector, is pleased to note the announcement by Savara, Inc. ("Savara" Nasdaq: SVRA) that it has entered into a $75 million royalty funding agreement with funds managed by RTW Investments, LP.  RTW Bio will participate in this investment through its commitment to the RTW-managed 4010 Royalty Fund. Savara is a clinical stage biopharmaceutical company focused on rare respiratory diseases.

The funding is subject to FDA approval of Savara's lead program, MOLBREEVI, a treatment in Phase 3 development for autoimmune pulmonary alveolar proteinosis (autoimmune PAP), a rare disease characterised by the abnormal build-up of surfactant in the alveoli of the lungs. Assuming FDA approval, the funding will support the U.S. launch and further commercialisation of MOLBREEVI, which would be the first approved drug for autoimmune PAP.

Rod Wong, CIO of RTW Investments, said, "The pivotal clinical trial demonstrated the potential of MOLBREEVI to treat autoimmune PAP and this investment reflects our confidence in Savara and the strong commercial potential of the therapy. We are proud to partner with the Savara management team and look forward to supporting their efforts to bring this meaningful treatment to patients."

Savara's announcement can be found here.

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About RTW Biotech Opportunities Ltd:

RTW Biotech Opportunities Ltd (LSE: RTW) is an investment fund focused on identifying transformative assets with high growth potential across the biopharmaceutical and medical technology sectors. Driven by a long-term approach to support innovative businesses, RTW Biotech Opportunities Ltd invests in companies developing next-generation therapies and technologies that can significantly improve patients' lives. RTW Biotech Opportunities Ltd is managed by RTW Investments, LP, a leading healthcare-focused entrepreneurial investment firm with deep scientific expertise and a strong track record of supporting companies developing life-changing therapies.

Visit the website at www.rtwfunds.com/rtw-biotech-opportunities-ltd for more information.

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The information in this announcement may include forward-looking statements, which are based on the current expectations and projections about future events, and in certain cases can be identified by the use of terms such as "may", "will", "should", "expect", "anticipate", "project", "estimate", "intend", "continue", "target", "believe" (or the negatives thereon) or other variations thereon or comparable terminology. These forward-looking statements, as well as those included in any related materials, are subject to risks, uncertainties and assumptions about the Company and/or its underlying investments, including, among other things, the development of the applicable entity's business, trends in its operating industry, expected use of financing proceeds and future capital expenditures and acquisitions. In light of these risks, uncertainties and assumptions, the events in the forward-looking statements may not occur.