The following amendment has been made to the 'Change of Registered Office' announcement released on
7 June 2023 at 07:00:03 under RNS No 8659B;

'France House' has been corrected to read as 'Frances House'.

All other details remain unchanged.

The full amended text is shown below.

Syncona Limited

Change of Company's Registered Office

7 June 2023

Syncona Limited announces that with effect from 14 June 2023 the Company's registered office address will change to:

Frances House

PO Box 273

Sir William Place

St. Peter Port

Guernsey, GY1 3RD

Channel Islands

[ENDS]

Enquiries

Syncona Ltd

Annabel Clark

Tel: +44 (0) 20 3981 7940

About Syncona

Syncona's purpose is to invest to extend and enhance human life. We do this by creating and building companies to deliver transformational treatments to patients in areas of high unmet need.

Our strategy is to create, build and scale companies around exceptional science to create a diversified portfolio of 20-25 globally leading healthcare businesses, across development stage and therapeutic areas, for the benefit of all our stakeholders. We focus on developing treatments for patients by working in close partnership with world-class academic founders and management teams. Our balance sheet underpins our strategy enabling us to take a long-term view as we look to improve the lives of patients with no or poor treatment options, build sustainable life science companies and deliver strong risk-adjusted returns to shareholders.

Copies of this press release and other corporate information can be found on the company website at: www.synconaltd.com