3 March 2026

Syncona Limited

("Syncona" or the "Company")

Results of General Meeting and Board Changes

At the general meeting of the Company held today, all resolutions set out in the notice of the general meeting (the "Notice") at the end of the explanatory circular published by the Company on 12 February 2026 (the "Circular") where duly passed. A poll was held on each of the resolutions proposed.

Resolution 1 was proposed as a special resolution and Resolution 2 was proposed as an ordinary resolution.

The results of the voting at the general meeting were as follows:

Notes:

*      Includes discretionary votes.

**    A vote withheld is not a vote in law and has not been counted in the votes for and against a resolution.

As at 6.00 p.m. on 27 February 2026, the Company's issued share capital consisted of 672,549,420 ordinary shares, and 64,356,396 shares held in treasury. Shares held in treasury do not have voting rights, therefore, the total voting rights in the Company as at 6.00 p.m. on 27 February 2026 were 608,193,024.

In compliance with the UK Listing Rules, a copy of all the resolutions passed at the General Meeting will be submitted to the National Storage Mechanism and will be available in due course for inspection at https://data.fca.org.uk/#/nsm/nationalstoragemechanism.

The full text of the resolutions can be found in the Notice at the end of the Circular, a copy of which is available on Syncona's website at https://www.synconaltd.com/investors/shareholder-information/shareholder-documents/.

Board Changes

As previously announced, Rob Hutchinson stepped down from the Company's board of directors (the "Board"). Following Rob's departure, all remaining directors will be members of the Board's committees with the exception of the Audit Committee whose members shall not include Melanie Gee, the Company's Chair, as recommended by the UK Corporate Governance Code.

As stated in the Circular, following the approval of the new investment policy, the Board intends to appoint a new non-executive director with investment company expertise and experience, whilst retaining five directors in total.

Enquiries

Syncona

Annabel Clark

Tel: +44 (0) 20 3981 7940

FTI Consulting

Ben Atwell / Natalie Garland-Collins / Tim Stamper

Tel: +44 (0) 20 3727 1000

IMPORTANT NOTICES

This announcement or any part of it does not constitute or form part of any offer to issue or sell, or the solicitation of an offer to acquire, purchase or subscribe for, any securities.

Certain statements contained in this announcement constitute "forward-looking statements" with respect to the results, financial condition, performance, developments or achievements of Syncona and its subsidiaries. Words such as "believes", "anticipates", "estimates", "expects", "intends", "plans", "aims", "potential", "will", "would", "could", "considered", "likely", "estimate" and variations of these words and similar future or conditional expressions, are intended to identify forward-looking statements but are not the exclusive means of identifying such statements. These statements and forecasts are inherently predictive, speculative and involve risks and uncertainties and assumptions that could cause actual results, financial condition, performance, developments or achievements to differ materially from those expressed or implied by these forward-looking statements and forecasts. Many of these risks, uncertainties and assumptions relate to factors that are beyond Syncona's ability to control, predict or estimate precisely. No representation or warranty is made, and no responsibility or liability is accepted, as to the achievement or reasonableness of, and no reliance should be placed on, such forward-looking statements. The forward-looking statements contained in this announcement speak only as of the date of this announcement. Syncona expressly disclaims any obligation or undertaking to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, unless required to do so by applicable law or regulation, the Financial Conduct Authority or London Stock Exchange plc.

Neither the content of Syncona's website (or any other website) nor the content of any website accessible from hyperlinks on Syncona's website (or any other website) is incorporated into or forms part of this announcement.

This announcement has been prepared for the purposes of complying with applicable law and regulation in the United Kingdom and the information disclosed may not be the same as that which would have been disclosed if this announcement had been prepared in accordance with the laws and regulations of any jurisdiction outside the United Kingdom.