Stephen HopsonAward02/07/202649,189 shares£18,199.93Stephen HopsonTransfer11/02/202640,352 shares£0.00Justin PlattPurchase24/12/2025158,309 sharesStephen HopsonTransfer24/12/202556,151 shares£0.00DateDirector/PDMRTypeSharesPriceValue02/07/2026Stephen HopsonAward49,18937.00£18,199.9311/02/2026Stephen HopsonTransfer40,3520.00£0.0024/12/2025Justin PlattPurchase158,309––24/12/2025Stephen HopsonTransfer56,1510.00£0.00
Open positions onlyAurelio Holding B.V.22/06/20267,434,000 shares3.97%Sona Asset Management (UK) LLP23/02/20267,966,907 shares4.25%Bradley Louis Radoff28/10/20255,627,125 shares3.00%Sona Asset Management (UK) LLP25/02/202532,202,894 shares5.08%The Wellcome Trust Limited as trustee of The Wellcome Trust08/01/20259,385,811 shares5.02%Nortrust Nominees Ltd23/09/202420,604,106 shares11.01%Coltrane Asset Management, L.P.02/09/20245,538,643 shares2.96%Coltrane Asset Management, L.P.14/06/20247,396,139 shares3.95%Coltrane Asset Management, L.P.13/05/20249,306,046 shares4.97%Aberforth Partners LLP09/02/202418,989,817 shares10.15%Morgan Stanley07/02/20244.79%The Wellcome Trust Limited as trustee of The Wellcome Trust01/02/20247,970,207 shares4.26%Morgan Stanley & Co. International plc31/01/202411,046,097 shares5.90%Morgan Stanley & Co. International plc01/12/202313,020,150 shares6.95%Bayberry Capital Partners LP22/11/20239,175,975 shares4.91%Coltrane Asset Management, L.P.15/08/20239,355,366 shares5.00%Coltrane Asset Management, L.P.01/08/20239,131,735 shares4.88%Morgan Stanley & Co. International plc26/07/202310,959,908 shares5.85%Morgan Stanley & Co. International plc22/03/202311,531,638 shares6.15%The Wellcome Trust Limited as trustee of The Wellcome Trust06/01/20235,731,036 shares3.06%Coltrane Asset Management, L.P.03/01/20239,359,447 shares5.00%DateShareholderShares HeldPercentage22/06/2026Aurelio Holding B.V.7,434,0003.97%23/02/2026Sona Asset Management (UK) LLP7,966,9074.25%28/10/2025Bradley Louis Radoff5,627,1253.00%25/02/2025Sona Asset Management (UK) LLP32,202,8945.08%08/01/2025The Wellcome Trust Limited as trustee of The Wellcome Trust9,385,8115.02%23/09/2024Nortrust Nominees Ltd20,604,10611.01%02/09/2024Coltrane Asset Management, L.P.5,538,6432.96%14/06/2024Coltrane Asset Management, L.P.7,396,1393.95%13/05/2024Coltrane Asset Management, L.P.9,306,0464.97%09/02/2024Aberforth Partners LLP18,989,81710.15%07/02/2024Morgan Stanley–4.79%01/02/2024The Wellcome Trust Limited as trustee of The Wellcome Trust7,970,2074.26%31/01/2024Morgan Stanley & Co. International plc11,046,0975.90%01/12/2023Morgan Stanley & Co. International plc13,020,1506.95%22/11/2023Bayberry Capital Partners LP9,175,9754.91%15/08/2023Coltrane Asset Management, L.P.9,355,3665.00%01/08/2023Coltrane Asset Management, L.P.9,131,7354.88%26/07/2023Morgan Stanley & Co. International plc10,959,9085.85%22/03/2023Morgan Stanley & Co. International plc11,531,6386.15%06/01/2023The Wellcome Trust Limited as trustee of The Wellcome Trust5,731,0363.06%03/01/2023Coltrane Asset Management, L.P.9,359,4475.00%
Stephen HopsonAward02/07/202649,189 shares£18,199.93Stephen HopsonTransfer11/02/202640,352 shares£0.00Justin PlattPurchase24/12/2025158,309 sharesStephen HopsonTransfer24/12/202556,151 shares£0.00DateDirector/PDMRTypeSharesPriceValue02/07/2026Stephen HopsonAward49,18937.00£18,199.9311/02/2026Stephen HopsonTransfer40,3520.00£0.0024/12/2025Justin PlattPurchase158,309––24/12/2025Stephen HopsonTransfer56,1510.00£0.00
Open positions onlyAurelio Holding B.V.22/06/20267,434,000 shares3.97%Sona Asset Management (UK) LLP23/02/20267,966,907 shares4.25%Bradley Louis Radoff28/10/20255,627,125 shares3.00%Sona Asset Management (UK) LLP25/02/202532,202,894 shares5.08%The Wellcome Trust Limited as trustee of The Wellcome Trust08/01/20259,385,811 shares5.02%Nortrust Nominees Ltd23/09/202420,604,106 shares11.01%Coltrane Asset Management, L.P.02/09/20245,538,643 shares2.96%Coltrane Asset Management, L.P.14/06/20247,396,139 shares3.95%Coltrane Asset Management, L.P.13/05/20249,306,046 shares4.97%Aberforth Partners LLP09/02/202418,989,817 shares10.15%Morgan Stanley07/02/20244.79%The Wellcome Trust Limited as trustee of The Wellcome Trust01/02/20247,970,207 shares4.26%Morgan Stanley & Co. International plc31/01/202411,046,097 shares5.90%Morgan Stanley & Co. International plc01/12/202313,020,150 shares6.95%Bayberry Capital Partners LP22/11/20239,175,975 shares4.91%Coltrane Asset Management, L.P.15/08/20239,355,366 shares5.00%Coltrane Asset Management, L.P.01/08/20239,131,735 shares4.88%Morgan Stanley & Co. International plc26/07/202310,959,908 shares5.85%Morgan Stanley & Co. International plc22/03/202311,531,638 shares6.15%The Wellcome Trust Limited as trustee of The Wellcome Trust06/01/20235,731,036 shares3.06%Coltrane Asset Management, L.P.03/01/20239,359,447 shares5.00%DateShareholderShares HeldPercentage22/06/2026Aurelio Holding B.V.7,434,0003.97%23/02/2026Sona Asset Management (UK) LLP7,966,9074.25%28/10/2025Bradley Louis Radoff5,627,1253.00%25/02/2025Sona Asset Management (UK) LLP32,202,8945.08%08/01/2025The Wellcome Trust Limited as trustee of The Wellcome Trust9,385,8115.02%23/09/2024Nortrust Nominees Ltd20,604,10611.01%02/09/2024Coltrane Asset Management, L.P.5,538,6432.96%14/06/2024Coltrane Asset Management, L.P.7,396,1393.95%13/05/2024Coltrane Asset Management, L.P.9,306,0464.97%09/02/2024Aberforth Partners LLP18,989,81710.15%07/02/2024Morgan Stanley–4.79%01/02/2024The Wellcome Trust Limited as trustee of The Wellcome Trust7,970,2074.26%31/01/2024Morgan Stanley & Co. International plc11,046,0975.90%01/12/2023Morgan Stanley & Co. International plc13,020,1506.95%22/11/2023Bayberry Capital Partners LP9,175,9754.91%15/08/2023Coltrane Asset Management, L.P.9,355,3665.00%01/08/2023Coltrane Asset Management, L.P.9,131,7354.88%26/07/2023Morgan Stanley & Co. International plc10,959,9085.85%22/03/2023Morgan Stanley & Co. International plc11,531,6386.15%06/01/2023The Wellcome Trust Limited as trustee of The Wellcome Trust5,731,0363.06%03/01/2023Coltrane Asset Management, L.P.9,359,4475.00%
